KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.

@article{Enkhbaatar2013KDM5BHD,
  title={KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family.},
  author={Zanabazar Enkhbaatar and Minoru Terashima and Dulamsuren Oktyabri and Shoichiro Tange and Akihiko Ishimura and Seiji Yano and Takeshi Suzuki},
  journal={Cell cycle},
  year={2013},
  volume={12 13},
  pages={
          2100-12
        }
}
Histone methylation is implicated in various biological and pathological processes including cancer development. In this study, we discovered that ectopic expression of KDM5B, a histone H3 lysine 4 (H3K4) demethylase, promoted epithelial-mesenchymal transition (EMT) of cancer cells. KDM5B increased the expression of transcription factors, ZEB1 and ZEB2… CONTINUE READING