KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.

@article{Kim2012KDM3BIT,
  title={KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.},
  author={Ji-young Kim and Kee-Beom Kim and Gwang Hyeon Eom and Nakwon Choe and Hae Jin Kee and Hye-Ju Son and Si-Taek Oh and Dong-wook Kim and Jhang Ho Pak and Hee Jo Baek and Hoon Kook and Yoonsoo Hahn and Hyun Kook and Debabrata Chakravarti and Sang-Beom Seo},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 14},
  pages={2917-33}
}
Histone lysine methylation and demethylation are considered critical steps in transcriptional regulation. In this report, we performed chromatin immunoprecipitation with microarray technology (ChIP-chip) analysis to examine the genome-wide occupancy of H3K9-me2 during all-trans-retinoic acid (ATRA)-induced differentiation of HL-60 promyelocytic leukemia cells. Using this approach, we found that KDM3B, which contains a JmjC domain, was downregulated during differentiation through the recruitment… CONTINUE READING
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