KDM1 is a novel therapeutic target for the treatment of gliomas

  title={KDM1 is a novel therapeutic target for the treatment of gliomas},
  author={Gangadhara Reddy Sareddy and Binoj Chandrasekharan Nair and Samaya K. Krishnan and Vijay Kumar Gonugunta and Quanguang Zhang and Takayoshi Suzuki and Naoki Miyata and Andrew J. Brenner and Darrell W Brann and Ratna K Vadlamudi},
Glioma development is a multistep process, involving alterations in genetic and epigenetic mechanisms. Understanding the mechanisms and enzymes that promote epigenetic changes in gliomas are urgently needed to identify novel therapeutic targets. We examined the role of histone demethylase KDM1 in glioma progression. KDM1 was overexpressed in gliomas and its expression positively correlated with histological malignancy. Knockdown of KDM1 expression or its pharmacological inhibition using… CONTINUE READING
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Zeleznik-Le NJ: Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML

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