KDM 5 B demethylates H 3 K 4 to recruit XRCC 1 and promote chemoresistance

@inproceedings{Xu2018KDM5B,
  title={KDM 5 B demethylates H 3 K 4 to recruit XRCC 1 and promote chemoresistance},
  author={Wenxia Xu and Bingluo Zhou and Xiaoya Zhao and Liyuan Zhu and Jinye Xu and Zhinong Jiang and Dingwei Chen and Qi and Yang Rongshui and Mengjiao Han and Lifeng Feng and Shouyu Wang and X Wang and Jimmy Jianheng Zhou and Hong Chuan Jin},
  year={2018}
}
Chemotherapy is the main treatment for human cancers including gastric cancer. However, in response to chemotherapeutic drugs, tumor cells can develop drug resistance by reprogramming intracellular metabolic and epigenetic networks to maintain their intrinsic homeostasis. Previously, we have established cisplatin-resistant gastric cancer cells as a drug resistant model, and elucidated the XRCC1 as the core DNA repair mechanism of drug resistance. This study investigated the regulation of XRCC1… CONTINUE READING

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SHOWING 1-10 OF 43 REFERENCES

Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein

M GLee, J Norman, A Shilatifard, R. Shiekhattar
  • Cell
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Emerging roles of linker histones in regulating chromatin structure and function

D VFyodorov, B RZhou, A ISkoultchi, Y. Bai
  • Nat Rev Mol Cell Biol
  • 2017
VIEW 1 EXCERPT