KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.

@article{Janssen2004KClEC,
  title={KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.},
  author={Luke Jeffrey Janssen and Tracy Tazzeo and Jianmin Zuo and Evi Pertens and Shaf H Keshavjee},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 4},
  pages={L852-8}
}
Airway smooth muscle (ASM) cells express voltage-dependent Ca2+ channels, primarily of the L-subtype. These may play a role in excitation-contraction coupling of ASM, although other signaling pathways may also contribute: one of these includes Rho and its downstream effector molecule Rho-associated kinase (ROCK). Although voltage-dependent Ca2+ influx and Rho/ROCK signaling have traditionally been viewed as entirely separate pathways, recent evidence in vascular smooth muscle suggest… CONTINUE READING