KCl cotransport is an important modulator of human cervical cancer growth and invasion.

@article{Shen2003KClCI,
  title={KCl cotransport is an important modulator of human cervical cancer growth and invasion.},
  author={M R Shen and C. -S. Chou and K F Hsu and Yueh-Mei Hsu and Wen-Tai Chiu and Ming-Jer Tang and Seth L Alper and J C John Clive Ellory},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 41},
  pages={39941-50}
}
Cervical cancer is a major world health problem for women, but the pathophysiology of this disease has received scant attention. Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. Functional assays of KCl cotransport activation by osmotic swelling, staurosporine, and N-ethylmaleimide indicate that removal of the N-terminal 117… CONTINUE READING