KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation

@article{Lin2010KChIP4aRK,
  title={KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation},
  author={Lin Lin and Wei Sun and Andrew M. Wikenheiser and Faith Kung and D. A. Hoffman},
  journal={Molecular and Cellular Neuroscience},
  year={2010},
  volume={43},
  pages={315-325}
}
  • Lin Lin, Wei Sun, +2 authors D. A. Hoffman
  • Published in
    Molecular and Cellular…
    2010
  • Biology, Medicine
  • Voltage-gated potassium (Kv) channels play important roles in regulating the excitability of myocytes and neurons. Kv4.2 is the primary alpha-subunit of the channel that produces the A-type K(+) current in CA1 pyramidal neurons of the hippocampus, which is critically involved in the regulation of dendritic excitability and plasticity. K(+) channel-interacting proteins, KChIPs (KChIP1-4), associate with the N-terminal of Kv4.2 and modulate the channel's biophysical properties, turnover rate and… CONTINUE READING

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