KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine.

  title={KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine.},
  author={Glenna C. L. Bett and Michael S. Morales and Harold C. Strauss and Randall L. Rasmusson},
  journal={Biochemical and biophysical research communications},
  volume={340 4},
Rapidly activating Kv4 voltage-gated ion channels are found in heart, brain, and diverse other tissues including colon and uterus. Kv4.3 can co-assemble with KChIP ancillary subunits, which modify kinetic behavior. We examined the affinity and use dependence of nifedipine block on Kv4.3 and its modulation by KChIP2b. Nifedipine (150 microM) reduced peak Kv4.3 current approximately 50%, but Kv4.3/KChIP2b current only approximately 27%. Nifedipine produced a very rapid component of open channel… CONTINUE READING

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