KChIP2 is a core transcriptional regulator of cardiac excitability

Abstract

Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous cardiac pathologies. However, it remains unknown if KChIP2 loss is merely a symptom or involved in disease… (More)
DOI: 10.7554/eLife.17304

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