KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

@inproceedings{Dolga2011KCa2CA,
  title={KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia},
  author={Amalia M. Dolga and N Terpolilli and Frauke Kepura and Ingrid Maria Nijholt and H-G Knaus and Beatrice D'Orsi and J H M Prehn and Ulrich L. M. Eisel and Thomas K. Plant and Nikolaus Plesnila and Carsten Culmsee},
  booktitle={Cell Death and Disease},
  year={2011}
}
Exacerbated activation of glutamate receptor-coupled calcium channels and subsequent increase in intracellular calcium ([Ca2+]i) are established hallmarks of neuronal cell death in acute and chronic neurological diseases. Here we show that pathological [Ca2+]i deregulation occurring after glutamate receptor stimulation is effectively modulated by small conductance calcium-activated potassium (KCa2) channels. We found that neuronal excitotoxicity was associated with a rapid downregulation of… CONTINUE READING