KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.

@article{Nie2008KCNQ4MA,
  title={KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.},
  author={Liping Nie},
  journal={Current opinion in otolaryngology & head and neck surgery},
  year={2008},
  volume={16 5},
  pages={
          441-4
        }
}
PURPOSE OF REVIEW This article provides an update on the current progress in identification of KCNQ4 mutations responsible for DFNA2, a subtype of autosomal dominant nonsyndromic progressive hearing loss. RECENT FINDINGS Hearing loss in pateints with DFNA2 usually start at high frequencies in their 20s and 30s, and then progress to more than 60 dB in less than 10 years, with middle and low frequencies often affected as well. To date, eight missense mutations and two deletions of the KCNQ4… CONTINUE READING

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