KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

@article{Wang1998KCNQ2AK,
  title={KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.},
  author={Hengliang Wang and Zongming Pan and Weimin Shi and Barry S. Brown and Randy S Wymore and Ira S. Cohen and Jane E. Dixon and David McKinnon},
  journal={Science},
  year={1998},
  volume={282 5395},
  pages={1890-3}
}
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current. 
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TTGACTCCCCATCCGACCT and GCCTTTGCCTTCTTTTGGG (forward reaction), and ACCGCGCACATGCATG and GTGACATGGGGAGGAAGAA (reverse reaction)

  • The KCNQ3 gene was initially identified as an expresse sequence, primers were designed, +7 authors IN with several combinations of the following oligonucleotides
  • Four independent clones were sequenced in their…
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