KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).

@article{Beitelshees2007KCNMB1GI,
  title={KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).},
  author={Amber Beitelshees and Yan Gong and Danxin Wang and Nicholas J. Schork and Rhonda M. Cooper-Dehoff and Taimour Y Langaee and Mark D. Shriver and Wolfgang Sadee and Harm J. Knot and Carl J Pepine and Julie A. Johnson},
  journal={Pharmacogenetics and genomics},
  year={2007},
  volume={17 9},
  pages={719-29}
}
OBJECTIVES We sought to determine whether polymorphisms in the large-conductance calcium and voltage-dependent potassium (BK) channel beta1 subunit gene, KCNMB1, are associated with blood pressure response to verapamil SR or adverse outcomes in the GENEtic substudy of the INternational VErapamil SR/trandolapril STudy (INVEST-GENES). BACKGROUND KCNMB1 is involved in calcium sensitivity and hypertension. The association between variability in KCNMB1 and calcium antagonist response, however, has… CONTINUE READING

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