KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas.

  title={KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas.},
  author={Masanobu Yamada and Yasuyo Nakajima and Ryo Taguchi and Takashi Okamura and Sumiyasu Ishii and Takuya Tomaru and Atsushi Ozawa and Nobuyuki Shibusawa and Satoshi Yoshino and Akiko Toki and Emi Ishida and Koshi Hashimoto and Tetsurou Satoh and Masatomo Mori},
  journal={Endocrine journal},
  volume={59 8},
Adrenal aldosterone-producing adenomas (APA) are rarely associated with the clear co-secretion of cortisol. Somatic mutations of the potassium channel KCNJ5 gene, with the hotspots G151R and L168R, have been recently identified in patients with APA. However, whether APAs that secrete cortisol have these mutations remains unclear. We examined three patients with APAs showing clear autonomous secretion of cortisol who possessed a 1 mg dexamethasone suppression test (DST) with a failure of the… CONTINUE READING
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