KCNE4 domains required for inhibition of KCNQ1.

  title={KCNE4 domains required for inhibition of KCNQ1.},
  author={Lauren J. Manderfield and M Leigh Anne Daniels and Carlos G Vanoye and Alfred L. George},
  journal={The Journal of physiology},
  volume={587 2},
Voltage-gated potassium (Kv) channels are modulated in distinct ways by members of the KCNE family of single transmembrane domain accessory subunits. KCNE4 has a dramatic inhibitory effect on KCNQ1 that differs substantially from the activating effects of KCNE1 and KCNE3. The structural features of KCNE4 that enable this behaviour are unknown. We exploited chimeras of KCNE1, KCNE3 and KCNE4 to identify specific domains responsible for the inhibitory effects on heterologously expressed KCNQ1… CONTINUE READING


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