KCNE3 Truncation Mutants Reveal a Bipartite Modulation of KCNQ1 K+ Channels

  title={KCNE3 Truncation Mutants Reveal a Bipartite Modulation of KCNQ1 K+ Channels},
  author={Steven D. Gage and William R Kobertz},
  journal={The Journal of General Physiology},
  pages={759 - 771}
The five KCNE genes encode a family of type I transmembrane peptides that assemble with KCNQ1 and other voltage-gated K(+) channels, resulting in potassium conducting complexes with varied channel-gating properties. It has been recently proposed that a triplet of amino acids within the transmembrane domain of KCNE1 and KCNE3 confers modulation specificity to the peptide, since swapping of these three residues essentially converts the recipient KCNE into the donor (Melman, Y.F., A. Domenech, S… CONTINUE READING
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