KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition.

@article{Kanda2011KCNE1AK,
  title={KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition.},
  author={Vikram A. Kanda and Anthony Lewis and Xianghua Xu and Geoffrey W. Abbott},
  journal={Biophysical journal},
  year={2011},
  volume={101 6},
  pages={1364-75}
}
Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation. Hence, the inactivation rate of heterotetrameric channels comprising both N-type and non-N-type (delayed rectifier) α-subunits depends upon the number of N-type α-subunits in the complex. As Kv channel inactivation and inactivation recovery rates regulate cellular excitability, the composition and expression of these… CONTINUE READING
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