KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis.

@article{Nishino1983KC404AP,
  title={KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis.},
  author={K. Nishino and H. Ohkubo and M. Ohashi and S. Hara and J. Kito and T. Irikura},
  journal={Japanese journal of pharmacology},
  year={1983},
  volume={33 2},
  pages={
          267-78
        }
}
The mode of action of a novel compound, 3-isobutyryl-2-isopropylpyrazolo [1,5-a]pyridine (KC-404), as a potential anti-allergic agent has been investigated. KC-404 was shown to have a direct bronchodilator activity in guinea pig trachea in vitro and in anesthetized guinea pig in vivo. In addition, KC-404 had a fairly selective antagonistic action against slow reacting substance of anaphylaxis (SRS-A) on guinea pig ileum in vitro. In anesthetized guinea pigs, ED50 values for intravenously and… Expand
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