KATP channels as molecular sensors of cellular metabolism.


In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K(ATP)) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of K(ATP) has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.

Citations per Year

3,405 Citations

Semantic Scholar estimates that this publication has 3,405 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Nichols2006KATPCA, title={KATP channels as molecular sensors of cellular metabolism.}, author={Colin G. Nichols}, journal={Nature}, year={2006}, volume={440 7083}, pages={470-6} }