KATP channel mutations in congenital hyperinsulinism.

  title={KATP channel mutations in congenital hyperinsulinism.},
  author={C{\'e}cile Saint-Martin and J. -P. Arnoux and Pascale de Lonlay and Christine Bellann{\'e}-Chantelot},
  journal={Seminars in pediatric surgery},
  volume={20 1},
Adenosine triphosphate (ATP)-sensitive potassium channels (K(ATP) channels) have a central role in the regulation of insulin secretion in pancreatic β cells. They are octameric complexes organized around the central core constituted by the Kir6.2 subunits. The regulation of the channel itself takes place on the sulfonylurea receptor-1 subunit. The channel opens and closes according to the balance between adenine nucleotide ATP and adenosine diphosphate. Hyperinsulinemic hypoglycemia (also named… CONTINUE READING