KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.

@article{Tie2018KAP1RE,
  title={KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.},
  author={Christopher H C Tie and Liane Fernandes and L. N. Conde and Luisa J. Robbez-Masson and Rebecca P. Sumner and Tom Peacock and Maria Teresa Rodriguez-Plata and Greta Mickute and Robert James Gifford and Greg J. Towers and Javier Herrero and Helen M Rowe},
  journal={EMBO reports},
  year={2018}
}
Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB zinc-finger proteins (KZNFs), but little is known about the regulation of ERVs in adult tissues. We observed that KAP1 repression of HERVK14C was conserved in differentiated human cells and performed KAP1 knockout to obtain an overview of KAP1 function. Our results show that… CONTINUE READING
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