KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

@article{Friedman1996KAP1AN,
  title={KAP-1, a novel corepressor for the highly conserved KRAB repression domain.},
  author={Joshua R Friedman and William J. Fredericks and David E. Jensen and David W. Speicher and Xiao Ping Huang and Eric G. Neilson and F. Rauscher},
  journal={Genes & development},
  year={1996},
  volume={10 16},
  pages={2067-78}
}
The KRAB repression domain is one of the most widely distributed transcriptional effector domains yet identified, but its mechanism of repression is unknown. We have cloned a corepressor, KAP-1, which associates with the KRAB domain but not with KRAB mutants that have lost repression activity. KAP-1 can enhance KRAB-mediated repression and is a repressor when directly tethered to DNA. KAP-1 contains a RING finger, B boxes, and a PHD finger; the RING-B1-B2 structure is required for KRAB binding… CONTINUE READING
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