KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer.

@article{Lee2004KAI1CI,
  title={KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer.},
  author={Ji Hee Lee and Sei Ryun Park and Kee-Oh Chay and Young-Woo Seo and Hyun Kook and Kyu Youn Ahn and Young Jin Kim and Kyung Keun Kim},
  journal={Cancer research},
  year={2004},
  volume={64 12},
  pages={4235-43}
}
We cloned recently an alternatively spliced variant of KAI1 mRNA that lacked exon 7 at the COOH-terminal region and showed differences in metastasis suppression when compared with the wild-type KAI1. These findings indicated that the COOH-terminal region of KAI1 is critical for its metastasis suppressor function. In this study, we isolated a cDNA clone of VANGL1, a member of the tetraspanin protein family, which interacted specifically with the COOH-terminal cytoplasmic domain of KAI1 in the… CONTINUE READING
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