KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2

@article{Mu2008KAI1CD82SH,
  title={KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2},
  author={ZhenBin Mu and Hua Quan Wang and Jing Zhang and Qingfang Li and Lisheng Wang and Xiaozhong Guo},
  journal={Science in China Series C: Life Sciences},
  year={2008},
  volume={51},
  pages={648-654}
}
We conducted a study concerning the suppressive mechanism of KAI1/CD82 on hepatoma cell metastasis. Hepatocyte growth factor (HGF) induces the migration of hepatoma cells through activation of cellular sphingosine kinase 1 (SphK1). Adenovirus-mediated gene transfer of KAI1 (Ad-KAI1) downregulates the SphK1 expression and suppresses the HGF-induced migration of SMMC-7721 human hepatocellcular carcinoma cells. Overexpression of KAI1/CD82 significantly elevates Sprouty2 at the protein level… CONTINUE READING
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