K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

@article{Rutherford1979K562HL,
  title={K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin},
  author={Tim R. Rutherford and John Brian Clegg and David J. Weatherall},
  journal={Nature},
  year={1979},
  volume={280},
  pages={164-165}
}
STUDIES of the regulation of human erythropoiesis and haemoglobin synthesis at different phases of development are hampered by the lack of a self-sustaining culture in which erythroid differentiation can be examined, and by difficulties in obtaining erythropoietic tissue in embryonic and early fetal life1. New insights into the regulation of murine erythropoiesis have been obtained by the study of established cultures of erythro-leukaemic cells (Friend cells) which can be induced to… CONTINUE READING
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