K313, a novel benzoxazole derivative, exhibits anti‐inflammatory properties via inhibiting GSK3β activity in LPS‐induced RAW264.7 macrophages

@article{Zhao2018K313AN,
  title={K313, a novel benzoxazole derivative, exhibits anti‐inflammatory properties via inhibiting GSK3$\beta$ activity in LPS‐induced RAW264.7 macrophages},
  author={Bo-Bo Zhao and Huijie Guo and Yang Liu and Xingyan Luo and Shu-xia Yang and Yantang Wang and Xiao Leng and Chunfen Mo and Qiang Zou},
  journal={Journal of Cellular Biochemistry},
  year={2018},
  volume={119},
  pages={5382 - 5390}
}
Benzoxazole and its derivatives have been widely studied in recent years due to their various biological properties. A previous study has demonstrated that K313 (1H‐indole‐2,3‐dione 3‐(1,3‐benzoxazol‐2‐ylhydrazone)), a novel benzoxazole derivative, inhibits T cell proliferation to yield immunosuppressive effects. However, there are no related reports about its anti‐inflammatory effects. In the present study, we investigated the anti‐inflammatory properties and the underlying molecular mechanism… Expand
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