K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa

  title={K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa},
  author={Edwin Kamau and Susana G. Campino and Lucas Amenga-Etego and Eleanor Drury and Deus I. Ishengoma and Kimberly Johnson and Dieudonn{\'e} N. Mumba and Mihir Kekre and William Yavo and Daniel Mead and Marielle Karine Bouyou-Akotet and Tobias O. Apinjoh and Lemu Golassa and Milijaona Randrianarivelojosia and Ben Andagalu and Oumou Maiga-Ascofar{\'e} and Alfred Amambua-Ngwa and Paulina Tindana and Anita Ghansah and Bronwyn Macinnis and Dominic Kwiatkowski and Abdoulaye A. Djimd{\'e}},
  booktitle={The Journal of infectious diseases},
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous… CONTINUE READING
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Absence of putative Plasmodium falciparum artemisinin resistance mutations in sub-Saharan Africa: A molecular epidemiologic study [Epub ahead of print

  • SM Taylor, CM Parobek, DK DeConti
  • J Infect Dis
  • 2015
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