K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.

@article{Westra1998KrasOM,
  title={K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.},
  author={William H Westra and Patrick Sturm and Paul Drillenburg and Michael A. Choti and David S. Klimstra and Jorge Albores-Saavedra and Anthony C Montag and G. Johan A. Offerhaus and Ralph H. Hruban},
  journal={The American journal of surgical pathology},
  year={1998},
  volume={22 10},
  pages={1247-54}
}
Osteoclast-like giant cell tumors (OCGTs) of the pancreas and liver are enigmatic tumors. Despite their striking morphologic resemblance to certain mesenchymal tumors of bone and tendon sheath, it has been suggested that these tumors may, in fact, arise from epithelial precursors. It is also unclear whether the osteoclast-like giant cells in OCGTs are neoplastic or nonneoplastic. We identified OCGTs of the pancreas and liver that were associated with atypical intraductal epithelial… CONTINUE READING
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