K-ras mutations in putative preneoplastic lesions in human colon.

@article{Pretlow1993KrasMI,
  title={K-ras mutations in putative preneoplastic lesions in human colon.},
  author={Theresa P. Pretlow and Thomas A. Brasitus and Nicole Fulton and C J Cheyer and Edwin L. Kaplan},
  journal={Journal of the National Cancer Institute},
  year={1993},
  volume={85 24},
  pages={2004-7}
}
BACKGROUND A mutation in c-K-ras (KRAS2) has long been implicated as one of the important early events in the development of a large proportion of human colon cancers. Aberrant crypt foci, putative preneoplastic lesions identified microscopically in wholemounts of colons, have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer. PURPOSE In this study, we asked whether the mutational… CONTINUE READING

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Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Colon structure (body structure)Is primary anatomic site of diseaseColon Carcinoma
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
Aberrant crypt foci , putative preneoplastic lesions identified microscopically in wholemounts of colons , have been shown to occur with high frequency in the colons of animals treated with colon carcinogens and in the grossly normal mucosas of patients with colon cancer . PURPOSE .
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