K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.

@article{Watanabe1999KrasMI,
  title={K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.},
  author={Hiroyuki Watanabe and Andrew Ha and Y X Hu and Koushiro Ohtsubo and Yasushi Yamaguchi and Yoshiharu Motoo and Takashi Okai and Daishu Toya and Naomi Tanaka and Norio Sawabu},
  journal={Cancer},
  year={1999},
  volume={86 8},
  pages={1441-8}
}
BACKGROUND K-ras mutations at codon 12 (KRM) have been detected in over 80% of tissues and pure pancreatic juice (PPJ) samples from patients with pancreatic carcinoma (PCa) and are promising genetic tumor markers. Aspirating PPJ not only requires technical skill, but is also exhausting for patients. The authors attempted to evaluate whether the detection of KRM in the duodenal aspirate (DA) obtained immediately after endoscopic retrograde cholangiopancreatography (ERCP), an easier sample… CONTINUE READING

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