K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.

@article{Anker1997KrasMA,
  title={K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.},
  author={Phillipe Anker and François Lefort and V Vasioukhin and Jacqueline Lyautey and Christine Lederrey and Xu Qi Chen and Maurice Stroun and Hugh E. Mulcahy and M. Farthing},
  journal={Gastroenterology},
  year={1997},
  volume={112 4},
  pages={1114-20}
}
BACKGROUND & AIMS Circulating DNA can be isolated from the plasma of healthy subjects and from patients with cancer. The aim of this study was to detect K-ras mutations in DNA extracted from the plasma of patients with colorectal cancer. METHODS Tumor and plasma DNA were extracted from 14 patients with colorectal cancer (stages A-D), and K-ras alterations were detected using a polymerase chain reaction assay that uses sequence-specific primers to amplify mutant DNA. These results were… CONTINUE READING

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