K-ras mutations and prognosis in large-bowel carcinomas.


BACKGROUND Colorectal carcinogenesis is regarded as a multistep process involving several genetic alterations, with mutation in the K-ras gene in about half of the tumours. We aimed at clarifying the role of this genetic alteration related to survival and clinicopathologic variables. METHODS One hundred large-bowel carcinomas operated on between 1978 and… (More)


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