K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

  title={K-ras mutations and benefit from cetuximab in advanced colorectal cancer.},
  author={Christos S. Karapetis and Shirin Khambata-Ford and Derek J. Jonker and Christopher J. O'Callaghan and Dongsheng Tu and Niall C Tebbutt and Robert John Simes and Haji Ibraheem Chalchal and Jeremy David Shapiro and Sonia Robitaille and Timothy Jay Price and Lois E. Shepherd and Heather J. Au and Christian Langer and Malcolm J. Moore and John R. Zalcberg},
  journal={The New England journal of medicine},
  volume={359 17},
BACKGROUND Treatment with cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor, improves overall and progression-free survival and preserves the quality of life in patients with colorectal cancer that has not responded to chemotherapy. The mutation status of the K-ras gene in the tumor may affect the response to cetuximab and have treatment-independent prognostic value. METHODS We analyzed tumor samples, obtained from 394 of 572 patients (68.9%) with… 

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