K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.

@article{Luo2010KrasE4,
  title={K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.},
  author={Feijun Luo and Hongtao Ye and Rifat A Hamoudi and Gehong Dong and Wenyan Zhang and Charles E. Patek and George Poulogiannis and Mark J Arends},
  journal={The Journal of pathology},
  year={2010},
  volume={220 5},
  pages={542-50}
}
K-ras encodes two isoforms, K-ras 4A and 4B, that are jointly affected by K-ras activating mutations, which are prevalent in colorectal cancer (CRC). CRC shows alterations in the expressed K-ras 4A : 4B isoform ratio in favour of K-ras 4B, in tumours both with and without K-ras mutations. The present study evaluated whether K-ras 4A expression can suppress colonic adenoma development in the absence of its oncogenic allele. Mice with homozygous targeted deletions of K-ras exon 4A (K-ras… CONTINUE READING