K-ras as a target for cancer therapy.

  title={K-ras as a target for cancer therapy.},
  author={Bret B. Friday and Araba A. Adjei},
  journal={Biochimica et biophysica acta},
  volume={1756 2},
The central role K-, H- and N-Ras play in regulating diverse cellular pathways important for cell growth, differentiation and survival is well established. Dysregulation of Ras proteins by activating mutations, overexpression or upstream activation is common in human tumors. Of the Ras proteins, K-ras is the most frequently mutated and is therefore an attractive target for cancer therapy. The complexity of K-ras signaling presents many opportunities for therapeutic targeting. A number of… CONTINUE READING