K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.

@article{Plowman2006Kras4A,
  title={K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.},
  author={Sarah J. Plowman and Rachel L. Berry and Scott A Bader and Feng Luo and Mark J Arends and David J. Harrison and Martin Hooper and Charles E. Patek},
  journal={Journal of experimental & clinical cancer research : CR},
  year={2006},
  volume={25 2},
  pages={259-67}
}
Ras activating mutations result in constitutive activation of Ras signalling pathways and occur in 30% of human malignancies. K-ras encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in lung, pancreatic and colorectal cancers. Using RT-PCR we examined their expression in normal adult human tissues and addressed whether K-ras splicing is altered in sporadic colorectal cancer by comparing normal colon with colon carcinoma… CONTINUE READING

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