K-ras 4 A and 4 B are Co-expressed Widely in Human Tissues , and Their Ratio is Altered in Sporadic Colorectal Cancer

@inproceedings{Plowman2006Kras4A,
  title={K-ras 4 A and 4 B are Co-expressed Widely in Human Tissues , and Their Ratio is Altered in Sporadic Colorectal Cancer},
  author={S. J. Plowman and Rachel L. Berry and S. A. Bader and F. Luo and Mark J Arends and D. J. Harrison and M. L. Hooper and Charles E. Patek},
  year={2006}
}
mon cause of cancer-related death in the Western hemisphere, and in the United Kingdom accounts for some 35,000 new cancer cases, and 16,000 deaths, each year (1). CRC is associated with genetic and epigenetic changes, including allelic losses in specific chromosomal arms, mutations of oncogenes, tumour suppressor genes and mismatch repair genes, micro-satellite instability, methylation changes in gene promoters and altered mRNA splicing (reviewed 2). Spliceosomal alterations are an intrinsic… CONTINUE READING