Corpus ID: 42370801

K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle.

@article{Trivedi1995KchannelOA,
  title={K-channel opening activity of dihydropyridine ZM244085: effect on 86Rb efflux and 3H-P1075 binding in urinary bladder smooth muscle.},
  author={S. Trivedi and L. Potter-Lee and M. McConville and J. Li and C. Ohnmacht and D. Trainor and S. Kau},
  journal={Research communications in molecular pathology and pharmacology},
  year={1995},
  volume={88 2},
  pages={
          137-51
        }
}
  • S. Trivedi, L. Potter-Lee, +4 authors S. Kau
  • Published 1995
  • Chemistry, Medicine
  • Research communications in molecular pathology and pharmacology
  • Zeneca ZM244085, 9-(3 cyanophenyl)hexahydro-1,8 acridinedione, is a novel dihydropyridine (DHP) which relaxes KCl precontracted urinary bladder smooth muscle in vitro. The effect of ZM244085 on low and high KCl induced contractions, 86Rb efflux and [3H]-P1075 binding in guinea pig bladder strips was investigated to characterize the K-channel opening properties of this compound. Since ZM244085 is a dihydropyridine its effect on DHP binding sites on Ca2+ channels was also investigated. ZM244085… CONTINUE READING
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