K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.

@article{Trivedi1995KchannelOA,
  title={K-channel opening activity of ZD6169 and its analogs: effect on 86Rb efflux and 3H-P1075 binding in bladder smooth muscle.},
  author={S. Trivedi and S. Stetz and L. Potter-Lee and M. McConville and J. Li and J. Empfield and C. Ohnmacht and K. Russell and F. J. Brown and D. Trainor},
  journal={Pharmacology},
  year={1995},
  volume={50 6},
  pages={
          388-97
        }
}
  • S. Trivedi, S. Stetz, +7 authors D. Trainor
  • Published 1995
  • Chemistry, Medicine
  • Pharmacology
  • Zeneca ZD6169, (S)-N-(4-benzoylphenyl)-3,3,3-trifluoro- 2-hydroxy-2-methylpropionamide, is a novel compound which relaxes urinary bladder smooth muscle in vitro. The effect of ZD6169 and two of its analogs on 86Rb efflux and 3H-P1075 binding in guinea pig bladder strips was investigated to characterize the K-channel opening properties of this compound. ZD6169 concentration dependently increased the rate of 86Rb efflux from guinea pig bladder strips. 86Rb efflux evoked by ZD6169 and its analogs… CONTINUE READING
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