K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells.

@article{Mazzanti1988KCK,
  title={K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells.},
  author={Michele Mazzanti and Louis J. DeFelice},
  journal={Biophysical journal},
  year={1988},
  volume={54 6},
  pages={1139-48}
}
By averaging the current that passes through cell-attached patches on beating heart cells, while measuring action potentials with a whole-cell electrode, we were able to study K channels during beating. In 7-d chick ventricle in 1.3 mM K physiological solutions at room temperature, delayed-rectifier channels have three linear conductance states: 60, 30, and 15 pS. The 60 and 15 pS conductances can exist alone, but all three states may appear in the same patch as interconverting conductance… CONTINUE READING