K-cell-mediated cytotoxicity induced with rat monoclonal antibodies. I. Antibodies of various isotypes differ in their ability to induce cytotoxicity mediated by rat and human effectors.


Among the rat antibodies tested in this study, monoclonals of IgG2a isotype were the best, IgG1 and IgG2b being also effective, for induction of K-cell-mediated cytotoxicity of relevant nucleated target cells by rat effectors (Nude spleen cells). The single rat monoclonal IgE tested was also active. Rat antibodies of IgM and IgA classes of immunoglobulins… (More)


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