K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors.

Abstract

The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based on inhibiting oncogenic Ras signaling. Attachment of Ras proteins to the plasma membrane is required for effective Ras signaling and is initiated by the enzyme farnesyl protein transferase. We found that in the presence of potent… (More)

Topics

4 Figures and Tables

Cite this paper

@article{Whyte1997KAN, title={K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors.}, author={David B. Whyte and Paul T. Kirschmeier and Tish Noel Hockenberry and I Nunez-Oliva and Lyn James and Joseph J. Catino and W. Robert Bishop and J K Pai}, journal={The Journal of biological chemistry}, year={1997}, volume={272 22}, pages={14459-64} }