K-RasV14I recapitulates Noonan syndrome in mice.

  title={K-RasV14I recapitulates Noonan syndrome in mice.},
  author={Isabel Hern{\'a}ndez-Porras and Salvatore Fabbiano and Alberto J. Schuhmacher and Alexandra Aicher and Marta Ca{\~n}amero and Juan Antonio C{\'a}mara and Lorena Cuss{\'o} and Manuel Desco and Christopher Heeschen and Francisca Mulero and Xos{\'e} R Bustelo and Carmen Guerra and Mariano Barbacid},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 46},
Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. NS also is associated with a risk for developing myeloproliferative disorders (MPD), including juvenile myelomonocytic leukemia (JMML). Mutations responsible for NS occur in at least 11 different loci including KRAS. Here we describe a mouse model for NS induced by K-Ras(V14I), a recurrent KRAS mutation in NS patients. K-Ras(V14I)-mutant mice… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…