K 562 Cells Resistant to Phorbol 12-Myristate 13-acetate-induced Growth Arrest : Dissociation of Mitogen-activated Protein Kinase Activation and Egr-1 Expression from Megakaryocyte Differentiation 1

Abstract

The K562 cell line undergoes megakaryocytic differentiation in response to phorbol 12-myristate 13-acetate (PMA) stimulation. This event correlates with mitogen-activated protein kinase activation, cell cycle arrest, and expression of the Egr-1 transcription factor. We have isolated K562 cells that are resistant to the growth-inhibitory action of PMA… (More)

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