K 562 , and Its Inhibition by Alkyl-lysophospholipid from Human Patients and in Human Leukemic Cell Lines HL 60 Phosphorylation System in Various Types of Leukemic Cells-dependent Protein 2 + Phospholipid-sensitive Ca Updated

@inproceedings{Helfman2006K5,
  title={K 562 , and Its Inhibition by Alkyl-lysophospholipid from Human Patients and in Human Leukemic Cell Lines HL 60 Phosphorylation System in Various Types of Leukemic Cells-dependent Protein 2 + Phospholipid-sensitive Ca Updated},
  author={D. M. Helfman and Katherine C. Barnes and Joseph M. Kinkade and William R. Vogler and Mamoru Shoji and Jen Feng Kuo},
  year={2006}
}
Phospholipid-sensitive Ca2+-dependent protein kinase (PL-CaPK), its endogenous substrate proteins, and regulation of the enzyme system by an antitumor agent alkyl-lysophospholipid were investigated in various types of leukemic cells (chronic myelocytic, acute myelocytic, and acute monocytic)from patients and in two cultured human leukemic cell lines (HL60 and K562). Exceedingly high levels of PL-Ca-PK, largely localized in the paniculate fraction, were found in all types and lines of leukemic… CONTINUE READING

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