K(v)7 channels: function, pharmacology and channel modulators.

@article{DalbyBrown2006Kv7CF,
  title={K(v)7 channels: function, pharmacology and channel modulators.},
  author={William Dalby-Brown and Henrik Hjelseth Hansen and Mads Gersdorff Korsgaard and Naheed R. Mirza and S{\o}ren Gytz Olesen},
  journal={Current topics in medicinal chemistry},
  year={2006},
  volume={6 10},
  pages={
          999-1023
        }
}
K(v)7 channels are unique among K(+) channels, since four out of the five channel subtypes have well-documented roles in the development of human diseases. They have distinct physiological functions in the heart and in the nervous system, which can be ascribed to their voltage-gating properties. The K(v)7 channels also lend themselves to pharmacological modulation, and synthetic openers as well as blockers of the channels, regulating neuronal excitability, have existed even before the K(v)7… CONTINUE READING
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