K(ATP) channels and insulin secretion disorders.

  title={K(ATP) channels and insulin secretion disorders.},
  author={Hanna Huopio and Show-Ling Shyng and Timo Otonkoski and Colin G. Nichols},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={283 2},
  • H. HuopioS. Shyng C. Nichols
  • Published 1 August 2002
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
ATP-sensitive potassium (K(ATP)) channels are inhibited by intracellular ATP and activated by ADP. Nutrient oxidation in beta-cells leads to a rise in [ATP]-to-[ADP] ratios, which in turn leads to reduced K(ATP) channel activity, depolarization, voltage-dependent Ca(2+) channel activation, Ca(2+) entry, and exocytosis. Persistent hyperinsulinemic hypoglycemia of infancy (HI) is a genetic disorder characterized by dysregulated insulin secretion and, although rare, causes severe mental… 

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