K+ depolarization induces RhoA kinase translocation to caveolae and Ca2+ sensitization of arterial muscle.

@article{Urban2003KDI,
  title={K+ depolarization induces RhoA kinase translocation to caveolae and Ca2+ sensitization of arterial muscle.},
  author={Nicole H Urban and Krystina M Berg and Paul H Ratz},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 6},
  pages={C1377-85}
}
KCl causes smooth muscle contraction by elevating intracellular free Ca2+, whereas receptor stimulation activates an additional mechanism, termed Ca2+ sensitization, that can involve activation of RhoA-associated kinase (ROK) and PKC. However, recent studies support the hypothesis that KCl may also increase Ca2+ sensitivity. Our data showed that the PKC inhibitor GF-109203X did not, whereas the ROK inhibitor Y-27632 did, inhibit KCl-induced tonic (5 min) force and myosin light chain (MLC… CONTINUE READING

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