K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.

@article{Heinrich2012KDE,
  title={K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.},
  author={Attila Heinrich and R{\'o}me{\'o} D. And{\'o} and Georg Turi and Bal{\'a}zs R{\'o}zsa and Be{\'a}ta Sperl{\'a}gh},
  journal={British journal of pharmacology},
  year={2012},
  volume={167 5},
  pages={1003-20}
}
BACKGROUND AND PURPOSE This study was undertaken to characterize the ATP, adenosine and glutamate outflow evoked by depolarization with high K(+) concentrations, in slices of rat hippocampus. EXPERIMENTAL APPROACH We utilized the microelectrode biosensor technique and extracellular electrophysiological recording for the real-time monitoring of the efflux of ATP, adenosine and glutamate. KEY RESULTS ATP, adenosine and glutamate sensors exhibited transient and reversible current during… CONTINUE READING