K+ current changes account for the rate dependence of the action potential in the human atrial myocyte.

@article{Maleckar2009KCC,
  title={K+ current changes account for the rate dependence of the action potential in the human atrial myocyte.},
  author={Mary M. Maleckar and Joseph L. Greenstein and Wayne R Giles and Natalia A. Trayanova},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 4},
  pages={
          H1398-410
        }
}
Ongoing investigation of the electrophysiology and pathophysiology of the human atria requires an accurate representation of the membrane dynamics of the human atrial myocyte. However, existing models of the human atrial myocyte action potential do not accurately reproduce experimental observations with respect to the kinetics of key repolarizing currents or rate dependence of the action potential and fail to properly enforce charge conservation, an essential characteristic in any model of the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 66 CITATIONS, ESTIMATED 25% COVERAGE

How computer simulations of the human heart can improve anti-arrhythmia therapy.

  • The Journal of physiology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 10 Citations per year over the last 3 years

  • 41% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Similar Papers

Loading similar papers…